A parallel downregulation of the NPAS4 protein interactor Arnt and its binding partner Hif3a mRNA were observed, as well as reduced transcript levels of downstream factors Slc2a12 and Rora (which is responsible for ataxia and intellectual deficits [178,179]), contrasting with upregulation of the alternative interactor Arnt2 mRNA [180,181,182,183,184]. The gene discussed is HIF3A; the disease is cerebellar ataxia.