The decreased mRNA levels of inositol-trisphosphate receptor Itpr1, and of Cadps2 (the Ca2+-dependent release activator for neurotransmitters, neuropeptides and neurotrophins), might be underlying contributors to this generalised pathology, given that loss-of-function of both downregulated factors results in cerebellar ataxia [154,164,167,168,169]. This evidence concerns the gene BDNF and aceruloplasminemia.