TNF and rheumatoid arthritis: Being in the high-risk group for TNF DNA-methylation was frequently observed in RA (150/190 (79%) compared to non-RA (18/94 (19%)), with a high predictive value (OR = 15.8 (8.25–28.25), p = 2.2 × 10−22, AUC = 0.799 (0.750–0.848)).