Strategy 2: We search publicly available DNA methylation datasets using the 450k DNA methylation arrays for additional cell types, such as CD4+ and CD8+ T-cells, B and NK-cells, monocytes for PBMC, and neutrophils, eosinophils, and granulocytes for WB (detailed in Supplementary Table S1) from healthy control (HC) and any datasets in RA patients (early and established disease). The gene discussed is CD4; the disease is rheumatoid arthritis.