CASP8 and cancer: Taken together, the above results suggest that the metabolic control of YAP/TAZ-TEAD transcriptional activity by the mevalonate pathway may represent an important mechanism controlling the expression of cFLIP (Figure 7), a key modulator of caspase-8 activity, and thus regulates the response of cancer cells to the clustering of proapoptotic receptors by death ligand TRAIL.