To demonstrate the importance of the loss of cFLIP proteins observed in cells treated with simvastatin or by targeting YAP/TAZ-TEAD signaling in the sensitization to TRAIL-induced apoptosis, we depleted both cFLIP isoforms in A549 cancer cells with a siRNA oligonucleotide set prior to treatment with TRAIL. Here, TNFSF10 is linked to cancer.