In our study, we demonstrate that inhibiting with statins the activity of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway [12,13], down-regulates cFLIP levels and facilitates the activation of an apoptotic process by TRAIL in different human cancer cell lines, by hindering the nuclear localization of the transcriptional coactivators YAP and TAZ. This evidence concerns the gene HMGCR and cancer.