SUMO2 and fragile X-associated tremor/ataxia syndrome: To quantify the increase of SUMO2/3 in FXTAS brain nuclei, western blot analyses were carried out in tissue lysates from the prefrontal cortex, hippocampus, and cerebellar vermis of FXTAS patients (n = 2) and controls (n = 2) as well as in skin fibroblasts lysates from FXTAS patients (n = 4) and controls (n = 4).