The cell surface expression of WT-PD-L1 remained intact when MDA cells were treated with kifunensine (Figure 6B), yet the ability of PD-L1 to promote CXCL8 release and invasion of the tumor cells in cell-autonomous and PD-1-induced manners was prominently reduced upon kifunensine treatment (Figure 6C; cell proliferation was not affected by kifunensine). This evidence concerns the gene CXCL8 and neoplasm.