CD274 and neoplasm: Here, we determined tumor growth and metastasis of WT-PD-L1 cells, compared with cells in which PD-L1 was mutated at the N35 and N219 sites; these two sites were selected for the in vivo studies in view of the fact that they had the strongest involvement in regulating the cell-autonomous, pro-metastatic functions of PD-L1 in MDA cells in vitro (Figure 8).