We found known COVID-19-related gene sets in hepatocytes and macrophages (‘Coronavirus disease - COVID-19’ in the KEGG database), including TMPRSS2, EGFR, PLCG2, MAPK14, FOS, JUN, IFNAR1, C5AR1, CFB, C8G, MASP1, FGA, FGB, FGG in addition to multiple ribosomal-related transcripts, p<1e-6 (Supplementary file 3). The gene discussed is C8G; the disease is COVID-19.