CD8A and hepatocellular carcinoma: showed that in hepatocellular carcinoma, exosomes from exhausted CD8(+) T cells with programmed cell death 1 and T‐cell immunoglobulin and mucin domain‐containing protein 3 positivity were taken up by other non‐exhausted CD8(+) T cells, and impaired their function by reducing IFN‐γ and IL‐2 expression.53