By applying 1.2 Pa shear stress on osteosarcoma (MG63, Saos-2) and chondrosarcoma (SW1353) cell monolayers, it was found that it induced G2/M cell cycle arrest.30 A more recent study of the same research group found that high shear stresses of 2 Pa induced upregulation of stearoyl-CoA desaturases-1 (SCD-1) levels in human osteosarcoma MG63 cells, which may have an auto-protective role in cell survival. Here, SCD is linked to osteosarcoma.