GSEA showed that low‐risk tumors were enriched with gene sets related to normal brain development and function (Figure 6B; Table S3), while high‐risk tumors were enriched with a variety of cancer‐promoting signatures and especially those relevant to DNA damage response, glucose metabolism, fatty acid metabolism, NF‐kB activation, extracellular matrix (ECM) remodeling, immune response, and immune cell function (Figure 6C; Table S3). The gene discussed is NFKB1; the disease is cancer.