In a study on HIF responding to hypoxia and promoting tumour cell metastasis by activating the transcription of glutamine metabolic enzyme in tumour cells, it was pointed out that in human glioblastoma (GBM), hypoxia could bind to the hypoxia response element of human GPT2 gene through hypoxia-inducible factor 1 (HIF1) rather than HIF2, leading to increased GPT2 transcription and promoting tumour cell proliferation and metastasis under hypoxia. This evidence concerns the gene HIF1A and glioblastoma.