In addition, the deletion of TG2 can lead to an increase in CD8+ T cell infiltration and a decrease in the number of myeloid cells through a cytokine-induced increase in STAT1 and weakened STAT3 phosphorylation in T cells, causing metastatic cancer cells to exhibit interferon-gamma (IFN-γ)-responsive gene labelling and undergo apoptosis [115].It can inhibit tumour metastasis by combining multiple aspects [116]. Here, CD8A is linked to neoplasm.