GOT1 and cancer: However, in a study on the inhibition of cancer progression, researchers confirmed that α-ketoglutarate esters elicit death of OXPHOS-deficient cancer cells by elevating intracellular aKG and thereby sequestering nitrogen from aspartate through GOT1, leading to the interruption of oxidative phosphorylation progression in in situ and metastatic cancer cells and their death [64].