Given the well-known phenomenon that CBF is directly coupled to neuronal activity and that it fluctuates synchronously in specific brain regions that form functional networks, CBF-based studies of resting-state brain networks and functional connectivity (FC) patterns are possible14 and have been used to evaluate clinical populations, such as epilepsy, migraine and schizophrenia.15-17 However, despite the many studies that have been carried out to date, there is a lack of literature on one aspect: the study of FC and topological organization of resting CBF fluctuations in mTBI patients. This evidence concerns the gene CEBPZ and migraine disorder.