Patients with T2DM aged 35–75 years with ≥1 of the following:-Previous CV disease-LDL cholesterol >190 mg/dl despite treatment-Albuminuria >300 mg/24 h or 200 mg/L or albumin/creatinine ratio on spot urine ≥300 mg/g-eGFR <30 ml/min/1.73 m2-Abnormal Q waves on ECG-Abnormal left ventricular function or hypertrophy on echocardiography-Peripheral artery atheromatous stenosis ≥50%. The gene discussed is ALB; the disease is cardiac hypertrophy.