In a real-world cohort study from the United States of 324,706 patients with T2DM and ASCVD, a statin was prescribed to 58.6% of patients, an angiotensin-converting enzyme inhibitor or an angiotensin-receptor blocker to 45.5%, and only 6.7% of patients were prescribed a cardioprotective glucose-lowering agent such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) or sodium-glucose cotransporter-2 inhibitors (SGLT2is) (41). This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.