LGALS3 and glaucoma: Consistent with previous studies showing galectin-3 expression by reactive astrocytes in mouse models of ischemia (75, 146) and physical injury (147) – as well as from patients with the demyelinating disease multiple sclerosis (148) – expression at the ONH rises in both DBA/2J and inducible OHT mouse models of glaucoma (55), and has been detected at the ONH in human glaucomatous tissue (149).