Additional studies revealed overexpression of decidual VEGF in ad libitum fed BPH/5 female mice implantation sites at e7.5 prior to higher circulating sFlt-1 and lower placental VEGF at mid-gestation compared to control mice (Olson et al., 2020; Reijnders et al., 2018; Woods et al., 2011). Here, VEGFA is linked to benign prostatic hyperplasia.