While excessive dietary restriction can be harmful, the method of food restriction utilized, pair feeding, which is matched to lean, gestation-matched control mice, acts to normalize obese BPH/5 mice weight and adiposity, and serum leptin by e7.5 (Reijnders et al., 2019), and has demonstrated improvement in fetal and maternal outcomes (Beckers et al., 2023). The gene discussed is LEP; the disease is benign prostatic hyperplasia.