Our study showed a moderate positive correlation between the degree of PSMA uptake,as assessed by the SUVmax, and tumor aggressiveness, as assessed by the ISUP grade.We also identified a moderate positive correlation between the SUVmax and serum PSA.Ergül et al.(21), inagreement with our data, also reported that a higher Gleason score and higher serumPSA translate to a higher SUVmax and greater tumor aggressiveness. This evidence concerns the gene KLK3 and neoplasm.