GCKR and metabolic dysfunction-associated steatotic liver disease: However, genetic polymorphism in the GCKR rs1260326 is associated with impaired hepatic lipid metabolism and secretion of very low density lipoprotein (VLDL), which can lead to hyperlipidemia and hepatic fat accumulation, and is significantly associated with the development of nonalcoholic fatty liver disease (NAFLD) in obese children and adolescents [7].