In light of IFN‐γ‐deficient model and the phenomena observed from TNF‐deficient model using intravital microscopy, IFN‐γ induced vascular degeneration in the process of angiogenesis, inducing an ischemic state in the tumor tissue, while TNF‐α causes vascular rupture in the tumor tissue and promotes the infiltration of circulating cells into the TME when destroying blood vessels.26 Here, IFNG is linked to neoplasm.