Concomitantly, the vaccines based on HLA‐II binding h‐TERT derived epitopes referred as universal cancer peptides (UCP) elicit Th1 and CD8+ T cell responses and promote the infiltration of h‐TERT‐specific CD8+ T cells,398, 399 confirming that MHC‐II‐restricted epitope‐based vaccines can mediate potent antitumor effects. This evidence concerns the gene TERT and cancer.