According to a transcriptome analysis based on human cancers, tumor‐infiltrating Treg cells also upregulate the expression of some immunosuppressive molecules, such as LAG‐3, TIM‐3, T cell immunoreceptor with Ig and ITIM domains (TIGIT), CTLA‐4,254, 255 and some molecules involved in activation, including ICOS, CD137, OX40, and GITR.256. This evidence concerns the gene ICOS and neoplasm.