The sequence analysis also demonstrated that helped CD8+ T cells gained a stronger extravasation potential by upregulation of chemokine receptors CXCR4 and CX3CR1,151 which could bind to CXCL12 and CX3CL1 from tumor cells, thus inducing CTLs infiltration into TME to exert antitumor effects.184, 185. This evidence concerns the gene CX3CR1 and neoplasm.