Among these clusters, cluster A exhibited a better prognosis as compared to the other two clusters, subsequent studies can be further classified in Cluster A. Ultimately, our analysis showed that the expression of LRRC59 in COAD samples was significantly higher than that in normal samples, and according to the clinical data, the overall survival of patients in the group with high expression of LRRC59 was higher. This evidence concerns the gene LRRC59 and colon adenocarcinoma.