In esophageal cancer, KDM5B, a histone 3 lysine 4 (H3K4) methylation regulator (31), can be downregulated by Let-7i to encourage the tri-methylation of H3K4 (H3K4me3) in the promoter region, consequently promoting the expression of the tumor suppressor SOX17 (32). This evidence concerns the gene SOX17 and esophageal cancer.