LEF1 and neoplasm: For example, lncRNAs such as TUG1, SOX2-OT, LINC04080, LINC00115, LINC00689, NORAD, SNHG1, and LEF1-AS1 activate the Wnt signaling pathway and promote tumor growth and metastasis by regulating other ncRNAs or proteins (Wang et al., 2019; Li et al., 2020a; Chen et al., 2020; Meng et al., 2020; Song et al., 2020; Zhang and Li, 2020; Peng et al., 2021).