LEF1-AS1 promotes PCa metastasis and serves as a competing endogenous RNA (ceRNA) for miR-328, thereby modulating Wnt/β-catenin pathway activity by regulating FZD2 and CD44, ultimately promoting androgen-independent PCa (AIPC) cell proliferation, migration, invasion, angiogenic ability, and tumor growth (Li et al., 2020d). Here, CD44 is linked to posterior cortical atrophy.