LEF1 and neoplasm: Moreover, LEF1-AS1 has been observed to promote PCa metastasis through the Wnt/β-catenin signaling pathway and function as a ceRNA for miR-328, thereby regulating the activity of the Wnt/β-catenin signaling pathway by regulating FZD2 and CD44, ultimately enhancing proliferation, migration, invasion, and angiogenic ability of AIPC cells and tumor growth (Li et al., 2020d).