Moreover, LEF1-AS1 has been observed to promote PCa metastasis through the Wnt/β-catenin signaling pathway and function as a ceRNA for miR-328, thereby regulating the activity of the Wnt/β-catenin signaling pathway by regulating FZD2 and CD44, ultimately enhancing proliferation, migration, invasion, and angiogenic ability of AIPC cells and tumor growth (Li et al., 2020d). This evidence concerns the gene CD44 and posterior cortical atrophy.