IL-6 has been implicated as an autocrine stimulator of cancer growth.6,12,45,46 The development of effective therapeutic options requires an understanding of IL-6 survival signaling in malignancies.49,50 Apoptosis inhibition is a well-studied strategy for cell survival.51 The mechanisms involved in proliferation and acute phase protein synthesis have been thoroughly defined in most investigations of IL-6 signaling in hepatic.52 A study by Bregmann12 showed that one of the essential factors of the development of hepatocellular carcinoma (HCC) is IL-6 trans-signaling. Here, IL6 is linked to cancer.