On the basis of ethno pharmacological utilization ofAzadirachta indica in cancer treatment,Azadirachta indica variant Indonesia and Philippines was evaluated for its anticancer effect by inhibiting IL-6/STAT-3 signaling pathways.In vitro andin vivo approaches were used for the explication of possible underlying mechanisms to rationalize the Ayurveda ethno medical uses of the plant from different geographical locations. Here, STAT3 is linked to cancer.