Growing evidence that OTU subfamily members are associated with many human diseases such as cancer (Lin et al., 2019), immunity (Zhang et al., 2018), inflammation (Zhao et al., 2020), DNA damage repair (Kato et al., 2014), etc. The dysfunction that occurs with abnormal OTUD3 expression can also lead to the development of tumors, diabetes, and neurodegenerative diseases. This evidence concerns the gene OTUD3 and neurodegenerative disease.