ACTN4 and colorectal cancer: In addition, ACTN4 promotes metastasis to lSymph nodes in colorectal cancer as well as induces epithelial mesenchymal transition and tumorigenesis in cervical cancer, and it can be inferred that OTUD3 is also involved in these processes by regulating ACTN4 (Honda et al., 2005; An et al., 2016).