We found that overexpression of cytoplasmic RNA-binding protein IGF2BP1 does not rescue the transcriptional activity of dnTCF7L2, and the disruption of β-Catenin/Tcf-dependent transcription included by dominant negative TCF7L2 is IGF2BP1-indepenent (Figure 1C), suggesting that IGF2BP1 is not involved in the ability of β-catenin/Tcf factors to bind with its DNA promoters and initiate transcription in CRC cells. The gene discussed is TCF7L2; the disease is colorectal carcinoma.