Some instances of the effects of this mode of inter-cellular communication include the onset and progression of preeclampsia in birthing women conducted by EVs enriched in S100 calcium-binding protein B (S100b), serpin peptidase inhibitor (PAI)-1, porphyria cutanea tarda (PCT), natriuretic peptide B (BNP), TGF-β, VEGFR1, and placental growth factor[35]. Here, NPPB is linked to preeclampsia.