TARDBP and amyotrophic lateral sclerosis: For example, in the context of amyotrophic lateral sclerosis (ALS), an incurable neurodegenerative disease, new evidence suggests that EVs package and transport key proteins involved in the progression of including SOD1, TDP-43, dipeptide-repeat proteins (DPRs), and fused in sarcoma (FUS) between glial cells[36].