Considering the limited research available on the association between years of education, cortical volume, cognitive function, and effect modifiers such as APOE ε4 carrier status during the preclinical phase, further longitudinal studies are needed that comprehensively analyze the impact of cognitive reserve proxy for the relationship between atrophy of AD-prone brain regions and cognitive change, together with Aβ and tau deposition. Here, MAPT is linked to Alzheimer disease.