Of all keywords, the most published and linked meaningful keywords included “astrocytes,” “brain,” “oxidative stress,” “neuroinflammation,” “microglia,” “inflammation,” “neurodegeneration,” “central nervous system,” “hippocampus,” and “mouse model.” As shown in Figure 6B, the number of publications focused on the association between GFAP and “aging,” “oxidative stress,” “inflammation,” “microglia,” “hippocampus,” and “amyloid” within the area of AD annually increased in general, and “immunohistochemistry” was applied more for this area. The gene discussed is GFAP; the disease is Alzheimer disease.