IL17A and inflammatory skin disease: By investigating the genes aligned with the instrumental variables of gut microbes showing a marked causal association with inflammatory skin disorders (refer to Table S14 in Supplementary 1) and conducting KEGG pathway enrichment analysis, we discerned a notable enrichment in inflammatory signaling pathways, including IL-17 signaling pathway, Chemokine signaling pathway and Cytokine-cytokine receptor interaction (refer to Table S15 in Supplementary 1, Figure S3 in Supplementary 2).