However, IFNactive neutrophils also occur in mild COVID-19, which is part of a coordinated interferon-stimulated gene (ISG) response across all major immune cell populations in the blood, whereas these ISG-expressing cells are systematically absent in patients with severe disease (93), consistent with the globally blunted type I and III IFN response characteristic of severe COVID-19 (73–75). The gene discussed is IFNA1; the disease is COVID-19.