In addition to the cis DR3-DQ2.5/DR4-DQ8 heterodimer, the heterozygote DR3-DQ2.5/DR4-DQ8 in trans heterodimer form encoded by DQA1*05:01-DQB1*03:02 is also very high risk for T1D (9). This evidence concerns the gene TNFRSF10A and type 1 diabetes mellitus.