HLA-DRB1 and type 1 diabetes mellitus: Seroconversion and development of T1D is associated with specific residues at both the DR and the DQ loci, the motif lysine, alanine, glycine at DRB1 β71, β74, β86 residues, which corresponds with DRB1*04:01, and glutamine, alanine, and aspartic acid at DQ α44, β57, and β135 residues, respectively, which correspond to DQA1*03:01-DQB1*03:02 (56, 57).