AQP4 and autoimmune disease: CCL2 has chemotactic activity towards monocytes and is one of the key chemokines regulating the migration and infiltration of monocytes/macrophages, which plays an important role in many diseases such as cancer, autoimmune diseases, neurological diseases, etc. In the autoimmune disease NMOSD, AQP4-IgG is a highly specific diagnostic marker with a specificity of 90%, but its causative factors are unknown.