AQP4 and neuromyelitis optica: In order to investigate the role of CCL2 in the astrocyte injury induced by AQP4-IgG, the authors established a model of astrocyte injury induced by NMO-IgG, and found that NMO-IgG treatment significantly decreased AQP4 levels on astrocyte cell membrane, meanwhile increased CCL2 levels, suggesting CCL2 might be associated with NMO-IgG-induced astrocyte injury.