In our study, we found that IL-10, CXCL10 (IP-10), D-dimer, VCAM-1, TNF-RII, and ICAM-1 were positively correlated with most of the significantly changed metabolites in lipid metabolism from HIV infection, but negatively correlated with changed metabolites in nucleotide metabolism. The gene discussed is ICAM1; the disease is HIV infectious disease.