In a study conducted by Amoozgar et al., it was demonstrated that the activation of GITR in Treg cells by an agonistic antibody (αGITR) led to the transformation of immunosuppressive Treg cells in the TME into immunostimulatory Th1-like CD4 T cells, enhancing the immune response against the tumor (73). The gene discussed is CD4; the disease is neoplasm.