MBP and type 1 diabetes mellitus: However, mismatched hybridization of exogenous and endogenous MHC receptor chains may limit their application In NOD mice, which spontaneously exhibit a disease that bears resemblance to human T1D, and in EAE, a model that mimics multiple sclerosis, TCR-engineered Tregs that are targeted toward MBP (myelin basic protein) effectively suppress the development and the progression of the disease.