BCL2 and breast cancer: Regarding the promotion of Cav-1 apoptosis in breast cancer cells, studies have found that docetaxel (DTX) can upregulate Cav-1 in MCF-7 and MDA-MB-231 breast cancer cells, thereby regulating apoptosis pathway-related proteins, Bcl-2 phosphorylation, p53 and Bax expression, and cleaved PARP cleavage (Kang et al., 2016).