Cavin-2 was found to be significantly positively correlated with the disease-free survival (DFS) and distant metastasis-free survival (DMFS) of breast cancer patients, and its loss of expression may be related to promoter methylation, while overexpression of Cavin-2 inhibited cell migration and reduced the tumor formation rate of lung metastatic tumors in NOD/SCID mice. The gene discussed is CAVIN2; the disease is breast cancer.