In cloned spheres derived from breast cancer cells, the expression of Cav-1 is significantly downregulated, and inhibition of Cav-1 can upregulate indicators related to tumor stemness (CD44/CD24), promote the self-renewal ability of breast cancer stem cells, and thus promote the malignant tumor behavior of breast cancer, such as EMT, invasion and metastasis (Yoon et al., 2019). This evidence concerns the gene CAV1 and neoplasm.