CAVIN2 and neoplasm: In addition, four semi-lim domain protein 1 (Fhl1) can induce Cavin-2 expression in Src protein kinase-transformed cells, independent of mitogen-activated protein kinase (MAPK) activity, and the expression of Fhl1 and Cavin-2 is significantly downregulated in breast cancer, suggesting that Cavin-2 plays a tumor suppressor role in breast cancer (Li et al., 2008).