LDHA and breast cancer: Therefore, high expression of Cav-1 can lead to a decrease in glucose in the cell and in the production of lactic acid and to low expression of lactate dehydrogenase A (LDH-A) and 3-phosphoinositol-dependent protein kinase-1 (PDK1), the key enzymes in glycolysis, thus inhibiting aerobic glycolysis and hence the proliferation of breast cancer cells.