IGF1R and breast carcinoma: Verma et al. (2010) found that Cavin-1 was related to Cav-1. In breast cancer SK-BR-3 cells, overexpression of Cavin-1 inhibited the formation of cell membrane tubules induced by Cav-1. Other studies have shown that receptor tyrosine kinase-like orphan receptor 1 (ROR1) maintains the downstream pro-survival signaling pathway in lung adenocarcinoma by promoting the interaction of Cavin-1 and Cav-1 (Yamaguchi et al., 2016). In addition, Cavin-1 and Cav-1 can bind to insulin-like growth factor-i receptor (IGF-IR) and regulate its internalization (Hamoudane et al., 2013).