Studies have shown that abnormal expression of Cav-1 can enhance EGFR signaling and increase the malignant potential of MCF-7 breast cancer cells, while overexpression of Cav-1 can enhance the cell growth inhibition ability of EGFR tyrosine kinase inhibitors (Agelaki et al., 2009). The gene discussed is EGFR; the disease is breast carcinoma.