Tian et al. (Tian et al., 2016) found that overexpression of Cavin-2 inhibited the proliferation and invasion ability of MDA-MB-231 cells, and loss of expression could activate the transforming growth factor TGF-β signaling pathway and induce an EMT-like phenotype in cells, suggesting that Cavin-2 could inhibit breast cancer progression by blocking the TGF-β signaling pathway. The gene discussed is TGFB1; the disease is breast cancer.