However, Lv et al. (2016) found that macrophage migration inhibitor (MIF) can induce the phosphorylation of Cav-1 and promote the transfer of high mobility group protein B1 (HMGB1) from the cytoplasm to the ECM, thus activating TLR4 signaling and promoting breast cancer metastasis. The gene discussed is HMGB1; the disease is breast cancer.