PRKDC and breast cancer: Zheng et al. (2019) proposed that overexpression of Cav-1 in MCF-7 and MDA-MB-231 cells could affect chemical sensitization by inhibiting eNOS/NO/ONOO pathway activity and oxidative damage. In addition, overexpression of Cav-1 in breast cancer can promote EGFR nuclear translocation, activate DNA-dependent protein kinase (DNAPK), induce DNA repair and enhance radiation resistance, suggesting that Cav-1 is associated with breast cancer radiotherapy (Zou et al., 2017).