Thus, to address this in a human population at heightened risk for inflammation-driven gastric cancer, we assessed HIF-1α expression levels in gastric tissue from patients with normal gastric mucosa, non-atrophic gastritis, multifocal atrophic gastritis, intestinal metaplasia, or gastric cancer (Supplementary Table S1, (Figure 1a-b)). This evidence concerns the gene HIF1A and chronic atrophic gastritis.