In gastric cancer, HIF-1α has been shown to inhibit apoptosis, while promoting proliferation, angiogenesis, metastasis, and stemness of gastric cancer cells.23 Further, HIF-1α expression is associated with increased invasion and metastasis and reduced overall survival in gastric cancer patients.12 Recent studies have also described non-transcriptional functions for HIF-1α that contrast with its canonical roles in carcinogenesis, via contributions to cell cycle arrest24,25 and inhibition of DNA replication.26 This evidence concerns the gene HIF1A and gastric cancer.