Consistent with previous evidence of independent relationships of WMH with Aβ12 and tau,13, 14 we quantified UWMC in Aβ‐ and tau‐affected regions separately and tested (1) associations of UWMC in AD pathology‐affected regions with cognition and (2) differences in UWMC‐and‐cognition associations between BA and nHW participants. This evidence concerns the gene MAPT and Alzheimer disease.