In MLR, MSI-H was significantly associated with location (right hemi-colon versus left hemi-colon, OR:2.90;95% CI:1.10–8.19;p = 0.036), CEA status (CEA positive versus CEA negative, OR:0.07;95% CI:0.01–0.31;p = 0.002), enhancement of pattern (inhomogeneous versus homogeneous, OR:2.55;95% CI:0.84–7.49;p = 0.089), LN metastasis number (OR:1.33;95% CI:1.14–1.56;p < 0.001), HR (1/3–2/3 group versus < 1/3 group, OR:6.05;95% CI:1.20–32.99;p = 0.031; > 2/3 group versus < 1/3 group, OR:36.73;95% CI:8.47–220.23;p < 0.001) and number of LNs with LD ≥ 8 mm (OR:1.32;95% CI:1.06–1.64;p = 0.010) (Table 3). Here, CEACAM5 is linked to lobular neoplasia.