Many studies have also proven that diosgenin can improve many complications of diabetes, such as diabetic nephropathy [39], nonalcoholic fatty liver disease in type 2 diabetes [40], cognitive impairment [41], as well as DR [42, 43] Therefore, this study used AKT, GAPDH, TNF, TP53, and IL-6 as the core targets of JGSQ's action, and the above five targets are the main molecules that regulate cell proliferation and inflammation. This evidence concerns the gene GAPDH and diabetic kidney disease.