Moreover, novel curcumin analogues and (-)-Epigallocatechin gallate (EGCG) reversed MDR1-mediated multidrug resistance in paclitaxel-resistant human breast cancer cells and 5-FU-resistant colorectal cancer, respectively [32, 33], indicating that other drugs also targeted MDR1 pathway to block chemotherapy resistance. This evidence concerns the gene ABCB1 and breast cancer.