Here, MEF2D‐driven DCC colonization was linked to NETs, the highly enriched niche components in the liver, an organ that is highly susceptible to cancer metastasis.[10, 11, 29] Additionally, except for ITGB1/4, MEF2D also regulates α integrin subunits that may interact with β integrins to form heterodimers,[6] although it remains unclear which may be the dominant heterodimers in DCCs. This evidence concerns the gene ITGB1 and cancer.