NETs are webs of chromatin‐DNA complexes released by necrotic neutrophils to promote microbial defense and also promotes cancer metastasis to the liver and lung.[8, 30] We found that NETs are enriched in the metastasized tumor and the adjacent liver tissues, but not in the liver at the early DCCs seeding stage.[31] This is consistent with a role of ITGB4 in engaging NETs‐DNA to maintain metastatic colonization, but not the seeding of DCCs. This evidence concerns the gene ITGB4 and cancer.