Motif enrichment analysis identified several TFs (Figure 1A; Figure S1A, Supporting Information), such as those from the HOX and Hippo‐TEAD families with known roles in tumor metastasis.[9, 18] However, among the top 10 enriched TFs, only MEF2D was highly expressed in HCC tissues, while the expression levels of the other identified TFs were extremely low (HOX family and CDX4) or comparable to normal tissues (CEBPB and SPI1) (Figure 1B). This evidence concerns the gene SPI1 and hepatocellular carcinoma.