MCL1 and non-small cell lung carcinoma: To support the generality of cardiac glycoside effects on Mcl-1, our group previously showed that ouabain, digitoxin, and the user-designed D6-MA induced Mcl-1 degradation in NSCLC cell lines under attached and detached conditions via the ubiquitin-proteosome proteolytic pathway [20, 21, 53].