ANXA5 and acute myeloid leukemia: A panel of human AML cell lines with different phenotypes and FAB subtypes, including KG-1 (early myeloblasts; M0), HL-60 (promyelocytes; M2), and PL-21 (promyelocytes; M3) cells [34, 35], were treated with various concentrations (0 − 300 nM) of digoxin, D6-MA, and ouabain, and apoptosis was analyzed by Annexin V/7-AAD assay at 48 h.