HIF1A and neoplasm: As feedback in glycolysis-cholesterol metabolic axis, highly glycolysis TAMs showed the ability to transmit myeloid-specific long noncoding RNA (lncRNA) and HIF-1α-stabilizing lncRNA to tumor cells [115], which was closely associated with cholesterol efflux mediated vesicle particles [116], consequently enhancing the glycolysis, tumor cells apoptotic resistance and constituting a feed-forward loop.