Furthermore, the findings of the present study found that serum level of CEA, CA19-9 and CA72-4 was significantly higher among H. pylori infected patients with SAT positive, and it might develop into GC as reported by many studies that atrophic gastritis is a well-recognized precancerous lesion, and it might develop into GC [59, 71–73]. Here, CEACAM5 is linked to chronic atrophic gastritis.