The current study was designed to: determine the serum levels of some tumor markers (CEA, CA19-9, CA72-4) in chronic patients with H. pylori infections and evaluate the association between serum tumor marker levels (CEA, CA19-9, and CA72-4) and different status of H. pylori infections according to different H. pylori diagnostic tests. This evidence concerns the gene CEACAM5 and neoplasm.