In addition, the results indicated that there were statistically significant difference of serum tumor markers levels based on infection duration, the (mean ± SD) of serum tumor markers levels CEA (3.99 ± 2.16) CA19-9 (26.86 ± 13.52), and CA72-4 (4.850 ± 2.806) respectively, which were the highest in the group with more than 3 years of H. pylori infection (Table 7) and (Table 8). Here, CEACAM5 is linked to neoplasm.