The use of autophagy enhancers such as rapamycin and trehalose protects ALS neurons and astrocytes, clear TDP43 and FUS79 stress granules, increase the survival of mice with mutation of SOD1 [88], TDP43 [89] or C9ORF72 [90], as well as increasing muscle function of mice with VCP mutations [91]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.