IFNA1 and Aicardi-Goutieres syndrome: Aicardi-Goutières syndrome (AGS) is a genetically heterogeneous disorder, originally defined as a progressive encephalopathy with an early age of onset, that is characterized by intracranial calcification, leukoencephalopathy, cerebral atrophy, and inappropriate induction of a type I interferon (IFN)-mediated immune response and belongs to the group of type I interferonopathies, a new heterogeneous group of autoinflammatory disorders [1].