In the present work, we aimed to explore the clinical therapeutic effect of sequential NIPPV + IMT in COPD patients and its association with SOCS5/JAK2/STAT3 signaling pathway, as well as the biological roles of SOCS5/JAK2/STAT3 signaling in oxidative stress damage in COPD mice model. This evidence concerns the gene STAT3 and chronic obstructive pulmonary disease.