These pathways are involved in CV comorbidities (such as Type II diabetes mellitus, Alzheimer’s disease, Cushing syndrome, and Dilated cardiomyopathy), cancers (such as gastric cancer, breast cancer, hepatocellular carcinoma), and the inflammatory pathway (such as signaling pathways regulating pluripotency of stem cells, mTOR signaling pathway, hippo signaling pathway, pi3k-Akt signaling pathway, and cAMP signaling pathway). This evidence concerns the gene PIK3CD and Cushing syndrome due to macronodular adrenal hyperplasia.