AR activation functions on MYC were evidenced by the findings that JQ1 inhibits MYC expression in AR(+) but not AR(-) PCa cell lines [26], AR binds to developmental enhancers in this locus, AR and MYC correlate in PCa expression, and AR wild-type represses MYC at lesser extent in comparison to its mutant counterparts deficient in DNA binding [3]. The gene discussed is AR; the disease is posterior cortical atrophy.