Exosomes derived from human umbilical cord mesenchymal stem cells decreased TNF-α and IL-1β levels, promoted M2-type macrophage polarization, and increased Treg cell production in the spleen in both in vitro and in vivo experiments, thereby improving nephritis and other serious organ damage and achieving the goal of treating SLE [70, 71]. This evidence concerns the gene IL1B and systemic lupus erythematosus.