Therefore, this review presents the mechanisms of macrophage polarization, inflammation-related signaling pathways (JAK/STAT, NF-κB, and PI3K/Akt), and the role of both in inflammatory immune skin diseases (psoriasis, AD, SLE, BD, etc.)to provide new directions for basic and clinical research of related diseases. Here, SOAT1 is linked to systemic lupus erythematosus.