Multiple Cox regression analysis (Table 1; Fig. 4) also revealed that CCDC69 expression level was an independent factor (high versus low, HR = 0.511, 95%CI (0.312–0.836), p = 0.007) of the OS of patients with breast cancer after adjustment for age, TNM stage, PAM50 classification, and radiation therapy status. This evidence concerns the gene CCDC69 and breast carcinoma.