CCDC69 and breast carcinoma: We further verified that CCDC69 was lower-expressed in breast cancer tissue compared with adjacent normal tissue both in TGCA database ( independent samples : unpaired t test, p<0.001; paired samples: paired t test, p<0.001; Fig. 1B,C) and in patients’ samples using qRT-PCR (Wilcoxon signed rank test, p = 0.0168; Fig. 1D).