Meanwhile, necrostatin 1 (Nec1) reduces DKD podocyte necroptosis and the subsequent damage by decreasing the expression levels of RIPK1 and RIPK3 (Xu et al. 2019).In addition, paeoniflorin (PF) directly binds and promotes the degradation of TNFR1 in podocytes in an STZ-induced mouse diabetes model and an HG-induced podocyte injury model. This evidence concerns the gene RIPK1 and diabetic kidney disease.