Meanwhile, Cheng et al. found that Caspase-11/4 and GSDMD-dependent podocyte pyroptosis were related to the development of DKD, and both caspase-11 and GSDMD knockout mice significantly improved the deterioration of renal function and the morphological changes in the glomerulus and podocyte (Cheng et al. 2021). This evidence concerns the gene GSDMD and diabetic kidney disease.